George Broussard (Duke Nukem Forever guy, to be reductive) tweeted this earlier:
What are people's thoughts? Bear in mind that he's specifically referring to the classic point and click adventure format - not genre hybrids or TWD style 'interactive narratives' or whatever. Just stop referencing Monkey Island and come up with a cool setting is his advice.
I don't really think he's right, tbh. Some sub-genres (which I think we can call the classic PnC now) are just niche and that's that. Splatter horror, say, is a niche movie genre, it's got its fandom and it will keep going forever and making money as long as budgets are pitched correctly and the occasional great one comes out, but you're not going to be able to make a billion dollars with one. You've got to do something different with your PnC otherwise it could be the perfect game and every single review would still include the words "but it's still the exact gameplay that Lucasarts perfected 40 years ago". Removing in-jokes and coming up with a "wider appealing" setting isn't going to solve that.