The second time you could actually drown, you mean?
I mean, Guybrush can (or must!) die to some degree in every game in the series. You can drown in Secret and Return and you can be dissolved by acid in LeChuck’s Revenge. You “die” in Curse because of mixing alcohol with medicine and you really, literally die in Tales (spoilers, heh). In Escape, there’s a time travel puzzle that allows you to straight up shoot a version of Guybrush and create a time paradox.
I guess my point is that Escape is underrated and would probably be lovely to play with a mouse, like Grim Fandango Remastered